Birthwort, plants of the genus Aristolochia, often found in the use of sorcery and religious rites of many peoples around the world. Ancient people believed that the extract from the leaves and stems of these plants are successfully helping women give birth, protect from snake venom, and many other ailments.
 |
| Scientists: Some Chinese drugs cause cancer |
The cells contain a toxic substance birthwort - aristolohovuyu acid, chronic use of which leads to kidney disease - malfunction of the kidneys.
The group of biologists led by Eun-Shiau Pu from the National Taiwan University in Taipei drew attention to the fact that the island of Taiwan, there is the world's highest incidence of cancer of the urinary tract. Moreover, among its inhabitants have a tradition of self-potions on the basis birthwort.
On social surveys, about one-third of the 200,000 residents of Taiwan respondents had used drugs or therapeutic use, based on extracts of Aristolochia.
Aristolohovoy acid molecule can connect with the molecules of DNA in cells of the urinary tract and other parts of the body and thus cause shifts in their structure. In some cases, replacing the correct nucleotides - building block of DNA - in the wrong can lead to fatal mutations, shut-off system to protect the genome and cell death.
Pu Yi and his colleagues studied the structure of the genome of tumor cells extracted from the urinary tract 151 patients Taiwanese hospitals, suffering from cancer.
In half of the colonies of cancer cells, scientists have found mutations in the gene p53, which is responsible for the synthesis of proteins of the same name - guardian of the genome. In all but one case, failure occurred due to the replacement of the genome nucleotide to another.
In most cases, a fatal failure of the gene was due to the fact that a molecule tyrosine was replaced by a molecule of adenine and vice versa. Similar changes occur in cells and in laboratory experiments in which biologists have turned the culture of healthy cells into cancer cells by adding acid to the nutrient medium.
As they note, this pattern of mutations characteristic of other diseases of the urinary tract - Balkan nephropathy, which are hotbeds in certain parts of Bosnia, Croatia and other countries of the peninsula from 1920.
It is believed that the disease is endemic has arisen due to the fact that the seeds birthwort lomonosovidnogo often found in barns and acid are absorbed into the body of local residents, along with the bread.
How to find Poo and his colleagues, the government of Taiwan and other countries should monitor and limit the spread of drugs based on birthwort, "to avoid a big problem for the health of society."
The group of biologists led by Eun-Shiau Pu from the National Taiwan University in Taipei drew attention to the fact that the island of Taiwan, there is the world's highest incidence of cancer of the urinary tract. Moreover, among its inhabitants have a tradition of self-potions on the basis birthwort.
On social surveys, about one-third of the 200,000 residents of Taiwan respondents had used drugs or therapeutic use, based on extracts of Aristolochia.
Aristolohovoy acid molecule can connect with the molecules of DNA in cells of the urinary tract and other parts of the body and thus cause shifts in their structure. In some cases, replacing the correct nucleotides - building block of DNA - in the wrong can lead to fatal mutations, shut-off system to protect the genome and cell death.
Pu Yi and his colleagues studied the structure of the genome of tumor cells extracted from the urinary tract 151 patients Taiwanese hospitals, suffering from cancer.
In half of the colonies of cancer cells, scientists have found mutations in the gene p53, which is responsible for the synthesis of proteins of the same name - guardian of the genome. In all but one case, failure occurred due to the replacement of the genome nucleotide to another.
In most cases, a fatal failure of the gene was due to the fact that a molecule tyrosine was replaced by a molecule of adenine and vice versa. Similar changes occur in cells and in laboratory experiments in which biologists have turned the culture of healthy cells into cancer cells by adding acid to the nutrient medium.
As they note, this pattern of mutations characteristic of other diseases of the urinary tract - Balkan nephropathy, which are hotbeds in certain parts of Bosnia, Croatia and other countries of the peninsula from 1920.
It is believed that the disease is endemic has arisen due to the fact that the seeds birthwort lomonosovidnogo often found in barns and acid are absorbed into the body of local residents, along with the bread.
How to find Poo and his colleagues, the government of Taiwan and other countries should monitor and limit the spread of drugs based on birthwort, "to avoid a big problem for the health of society."
.png "English"){kind=small}
0 comments:
Post a Comment